Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation.

@article{Anelli2009GlobalRO,
  title={Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation.},
  author={Viviana Anelli and Cristina Santoriello and Martin Distel and Reinhard W K{\"o}ster and Francesca D. Ciccarelli and Maria Caterina Mione},
  journal={Zebrafish},
  year={2009},
  volume={6 4},
  pages={417-24}
}
We have established a model of melanoma progression in zebrafish through the generation of transgenic lines specifically expressing oncogenic human HRAS in the melanocytic lineage. In these tumors we have carried out quantitative expression analysis of several putative cancer genes, from known and predicted cancer gene lists. In particular, we analyzed 39 out of 101 putative cancer genes identified with a bioinformatics approach and selected for the low frequency of duplication and the high… CONTINUE READING

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