Global regulatory logic for specification of an embryonic cell lineage.

  title={Global regulatory logic for specification of an embryonic cell lineage.},
  author={Paola Oliveri and Qiang Tu and Eric H. Davidson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 16},
Explanation of a process of development must ultimately be couched in the terms of the genomic regulatory code. Specification of an embryonic cell lineage is driven by a network of interactions among genes encoding transcription factors. Here, we present the gene regulatory network (GRN) that directs the specification of the skeletogenic micromere lineage of the sea urchin embryo. The GRN now includes all regulatory genes expressed in this lineage up to late blastula stage, as identified in a… CONTINUE READING
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