Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa.

@article{Juhas2004GlobalRO,
  title={Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa.},
  author={Mario Juhas and Lutz Wiehlmann and Birgit Huber and Doris Jordan and Joerg Lauber and Prabhakar Salunkhe and Anna Silke Limpert and Franz von Goetz and Ivo Steinmetz and Leo Eberl and Burkhard T{\"u}mmler},
  journal={Microbiology},
  year={2004},
  volume={150 Pt 4},
  pages={831-41}
}
Pathogenesis of Pseudomonas aeruginosa is controlled to a major extent by the two quorum-sensing systems las and rhl. The previously uncharacterized gene PA2591 was identified as a major virulence regulator, vqsR, in the quorum-sensing hierarchy. vqsR is a member of the LuxR family and possesses a las box in its upstream region. Transposon inactivation of vqsR abrogated the production of N-acylhomoserine lactones and the secretion of exoproducts and diminished bacterial virulence for… CONTINUE READING

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