Global regulation of Staphylococcus aureus genes by Rot.

  title={Global regulation of Staphylococcus aureus genes by Rot.},
  author={Battouli Sa{\"i}d-Salim and Paul M. Dunman and Fionnuala M McAleese and Daphne Macapagal and Evan Murphy and Peter J. McNamara and Staffan Arvidson and T. J. Foster and Steven J. Projan and Barry Kreiswirth},
  journal={Journal of bacteriology},
  volume={185 2},
Staphylococcus aureus produces a wide array of cell surface and extracellular proteins involved in virulence. Expression of these virulence factors is tightly controlled by numerous regulatory loci, including agr, sar, sigB, sae, and arl, as well as by a number of proteins with homology to SarA. Rot (repressor of toxins), a SarA homologue, was previously identified in a library of transposon-induced mutants created in an agr-negative strain by screening for restored protease and alpha-toxin. To… CONTINUE READING
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