• DOI:10.1038/nature10098
Corpus ID: 205224972

Global quantification of mammalian gene expression control

@article{Schwanhusser2011GlobalQO,
  title={Global quantification of mammalian gene expression control},
  author={Bj{\"o}rn Schwanh{\"a}usser and Dorothea Busse and N. Li and G. Dittmar and J. Schuchhardt and J. Wolf and W. Chen and M. Selbach},
  journal={Nature},
  year={2011},
  volume={473},
  pages={337-342}
}

• Björn Schwanhäusser, Dorothea Busse, +5 authors M. Selbach
• Published 2011
• Biology, Medicine
• Nature

Gene expression is a multistep process that involves the transcription, translation and turnover of messenger RNAs and proteins. Although it is one of the most fundamental processes of life, the entire cascade has never been quantified on a genome-wide scale. Here we simultaneously measured absolute mRNA and protein abundance and turnover by parallel metabolic pulse labelling for more than 5,000 genes in mammalian cells. Whereas mRNA and protein levels correlated better than previously thought… Expand