Global protein stability profiling in mammalian cells.

@article{Yen2008GlobalPS,
  title={Global protein stability profiling in mammalian cells.},
  author={Hsueh-Chi S. Yen and Qikai Xu and Danny M. Chou and Zhenming Zhao and Stephen J Elledge},
  journal={Science},
  year={2008},
  volume={322 5903},
  pages={918-23}
}
The abundance of cellular proteins is determined largely by the rate of transcription and translation coupled with the stability of individual proteins. Although we know a great deal about global transcript abundance, little is known about global protein stability. We present a highly parallel multiplexing strategy to monitor protein turnover on a global scale by coupling flow cytometry with microarray technology to track the stability of individual proteins within a complex mixture. We… CONTINUE READING
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