Global protein function prediction from protein-protein interaction networks

  title={Global protein function prediction from protein-protein interaction networks},
  author={Alexei V{\'a}zquez and Alessandro Flammini and Amos Maritan and Alessandro Vespignani},
  journal={Nature Biotechnology},
Determining protein function is one of the most challenging problems of the post-genomic era. The availability of entire genome sequences and of high-throughput capabilities to determine gene coexpression patterns has shifted the research focus from the study of single proteins or small complexes to that of the entire proteome. In this context, the search for reliable methods for assigning protein function is of primary importance. There are various approaches available for deducing the… CONTINUE READING
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