Global profiling of DNA methylation erasure in mouse primordial germ cells.

  title={Global profiling of DNA methylation erasure in mouse primordial germ cells.},
  author={Sylvain Guibert and Thierry Forn{\'e} and Michael Weber},
  journal={Genome research},
  volume={22 4},
Epigenetic reprogramming, characterized by loss of cytosine methylation and histone modifications, occurs during mammalian development in primordial germ cells (PGCs), yet the targets and kinetics of this process are poorly characterized. Here we provide a map of cytosine methylation on a large portion of the genome in developing male and female PGCs isolated from mouse embryos. We show that DNA methylation erasure is global and affects genes of various biological functions. We also reveal… CONTINUE READING
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