Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians

@article{SuarezKurtz2012GlobalPI,
  title={Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians},
  author={Guilherme Suarez-Kurtz and J{\'u}lia Pasqualini Genro and Manoel Odorico de Moraes and Elida Paula Benquique Ojopi and Sergio Danilo Juno Pena and Jamila Alessandra Perini and Andrea Kelly Ribeiro-dos-Santos and Marco Aur{\'e}lio Romano-Silva and Isabel Santana and Cl{\'a}udio Jos{\'e} Struchiner},
  journal={The Pharmacogenomics Journal},
  year={2012},
  volume={12},
  pages={267-276}
}
The impact of biogeographical ancestry, self-reported ‘race/color’ and geographical origin on the frequency distribution of 10 CYP2C functional polymorphisms (CYP2C8*2, *3, *4, CYP2C9*2, *3, *5, *11, CYP2C19*2, *3 and *17) and their haplotypes was assessed in a representative cohort of the Brazilian population (n=1034). TaqMan assays were used for allele discrimination at each CYP2C locus investigated. Individual proportions of European, African and Amerindian biogeographical ancestry were… CONTINUE READING
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