Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1.

@article{Yu2001GlobalPO,
  title={Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1.},
  author={Ning Yu and Zhongming Zhao and Y. X. Fu and Nyamkhishig N Sambuughin and Michelle Ramsay and Trefor Jenkins and Elina Leskinen and L{\'a}szl{\'o} Patthy and Lynn B. Jorde and Takashi Kuromori and Wen Li},
  journal={Molecular biology and evolution},
  year={2001},
  volume={18 2},
  pages={214-22}
}
Human DNA variation is currently a subject of intense research because of its importance for studying human origins, evolution, and demographic history and for association studies of complex diseases. A approximately 10-kb region on chromosome 1, which contains only four small exons (each <155 bp), was sequenced for 61 humans (20 Africans, 20 Asians, and 21 Europeans) and for 1 chimpanzee, 1 gorilla, and 1 orangutan. We found 52 polymorphic sites among the 122 human sequences and 382 variant… CONTINUE READING