Global organization of metabolic fluxes in the bacterium Escherichia coli

@article{Almaas2004GlobalOO,
  title={Global organization of metabolic fluxes in the bacterium Escherichia coli},
  author={Eivind Almaas and Baldvin Kovacs and Tam{\'a}s Vicsek and Zoltn Oltvai and A L Barabasi},
  journal={Nature},
  year={2004},
  volume={427},
  pages={839-843}
}
Cellular metabolism, the integrated interconversion of thousands of metabolic substrates through enzyme-catalysed biochemical reactions, is the most investigated complex intracellular web of molecular interactions. Although the topological organization of individual reactions into metabolic networks is well understood, the principles that govern their global functional use under different growth conditions raise many unanswered questions. By implementing a flux balance analysis of the… 

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