Global non-viral gene transfer to the primate brain following intravenous administration.

@article{Zhang2003GlobalNG,
  title={Global non-viral gene transfer to the primate brain following intravenous administration.},
  author={Yun Zhang and Felix Schlachetzki and William M Pardridge},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2003},
  volume={7 1},
  pages={11-8}
}
Expression plasmids encoding either luciferase or beta-galactosidase were encapsulated in the interior of an "artificial virus" comprised of an 85 nm pegylated immunoliposome, which was targeted to the rhesus monkey brain in vivo with a monoclonal antibody (MAb) to the human insulin receptor (HIR). The HIRMAb enables the liposome carrying the exogenous gene to undergo transcytosis across the blood-brain barrier and endocytosis across the neuronal plasma membrane following intravenous injection… CONTINUE READING

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