Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia

@article{Oosterom2018GlobalMI,
  title={Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia},
  author={Natanja Oosterom and Pieter H Griffioen and Marissa A. H. den Hoed and Rob Pieters and Robert de Jonge and Wim J. E. Tissing and Marry M M van den Heuvel-Eibrink and Sandra G. Heil},
  journal={PLoS ONE},
  year={2018},
  volume={13}
}
Background Children with acute lymphoblastic leukemia (ALL) often suffer from toxicity of chemotherapeutic drugs such as Methotrexate (MTX). Previously, we reported that 20% of patients receiving high-dose MTX developed oral mucositis. MTX inhibits folate metabolism, which is essential for DNA methylation. We hypothesize that MTX inhibits DNA methylation, which results into adverse effects. We studied DNA methylation markers during high-dose methotrexate treatment in pediatric acute… Expand
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