Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment

Abstract

The alteration of DNA methylation patterns are a key component of disease onset and/or progression. Our objective was to evaluate the differences in Long Interspersed Nuclear Element-1 (LINE-1) methylation levels, as a surrogate marker of global DNA methylation, between multiple sclerosis (MS) patients and healthy controls. In addition, we assessed the… (More)
DOI: 10.1038/s41598-017-09301-2

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