Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol.

@article{Cheng2014GlobalMN,
  title={Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol.},
  author={K K Cheng and Baek-Seok Lee and Takeshi Masuda and Takuro Ito and Kazutaka Ikeda and Akiyoshi Hirayama and Lingli Deng and Jiyang Dong and Kazuyuki Shimizu and Tomoyoshi Soga and Masaru Tomita and Bernhard O. Palsson and Martin Robert},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={3233}
}
Comparative whole-genome sequencing enables the identification of specific mutations during adaptation of bacteria to new environments and allelic replacement can establish their causality. However, the mechanisms of action are hard to decipher and little has been achieved for epistatic mutations, especially at the metabolic level. Here we show that a strain of Escherichia coli carrying mutations in the rpoC and glpK genes, derived from adaptation in glycerol, uses two distinct metabolic… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 12 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
22 Citations
56 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Similar Papers

Loading similar papers…