Global mRNA selection mechanisms for translation initiation

  title={Global mRNA selection mechanisms for translation initiation},
  author={Joseph L Costello and Lydia M. Castelli and William Rowe and Christopher J. Kershaw and David Talavera and Sarah S. Mohammad-Qureshi and P. F. Sims and Chris M Grant and Graham D Pavitt and Simon J. Hubbard and Mark P. Ashe},
  booktitle={Genome Biology},
The selection and regulation of individual mRNAs for translation initiation from a competing pool of mRNA are poorly understood processes. The closed loop complex, comprising eIF4E, eIF4G and PABP, and its regulation by 4E-BPs are perceived to be key players. Using RIP-seq, we aimed to evaluate the role in gene regulation of the closed loop complex and 4E-BP regulation across the entire yeast transcriptome. We find that there are distinct populations of mRNAs with coherent properties: one mRNA… CONTINUE READING
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