Global issues and opportunities for optimized retinoblastoma care.

@article{Gallie2007GlobalIA,
  title={Global issues and opportunities for optimized retinoblastoma care.},
  author={Brenda L. Gallie and Junyang Zhao and Kirk Vandezande and Abigail White and Helen Shuk-ying Chan},
  journal={Pediatric blood & cancer},
  year={2007},
  volume={49 7 Suppl},
  pages={1083-90}
}
The RB1 gene is important in all human cancers. Studies of human retinoblastoma point to a rare retinal cell with extreme dependency on RB1 for initiation but not progression to full malignancy. In developed countries, genetic testing within affected families can predict children at high risk of retinoblastoma before birth; chemotherapy with local therapy… CONTINUE READING