Global ischaemia induces a biphasic response of the mitochondrial respiratory chain. Anoxic pre-perfusion protects against ischaemic damage.

@article{Veitch1992GlobalII,
  title={Global ischaemia induces a biphasic response of the mitochondrial respiratory chain. Anoxic pre-perfusion protects against ischaemic damage.},
  author={Keith Veitch and A Hombroeckx and D Caucheteux and Hubert G Pouleur and Louis Hue},
  journal={The Biochemical journal},
  year={1992},
  volume={281 ( Pt 3)},
  pages={709-15}
}
Studies of Langendorff-perfused rat hearts have revealed a biphasic response of the mitochondrial respiratory chain to global ischaemia. The initial effect is a 30-40% increase in the rate of glutamate/malate oxidation after 10 min of ischaemia, owing to an increase in the capacity for NADH oxidation. This effect is followed by a progressive decrease in these oxidative activities as the ischaemia is prolonged, apparently owing to damage to Complex I at a site subsequent to the NADH… CONTINUE READING
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