Global impact of Salmonella pathogenicity island 2-secreted effectors on the host phosphoproteome.

@article{Imami2013GlobalIO,
  title={Global impact of Salmonella pathogenicity island 2-secreted effectors on the host phosphoproteome.},
  author={Koshi Imami and Amit P Bhavsar and Hongbing Yu and Nat F. Brown and Lindsay D. Rogers and Brett B. Finlay and Leonard J. Foster},
  journal={Molecular & cellular proteomics : MCP},
  year={2013},
  volume={12 6},
  pages={1632-43}
}
During the late stages of infection, Salmonella secretes numerous effectors through a type III secretion system that is encoded within Salmonella pathogenicity island 2 (SPI2). Despite the importance of SPI2 as a major virulence factor leading to the systemic spread of the bacteria and diseases, a global view of its effects on host responses is still lacking. Here, we measured global impacts of SPI2 effectors on the host phosphorylation and protein expression levels in RAW264.7 and in HeLa… CONTINUE READING

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