Global identification of hnRNP A1 binding sites for SSO-based splicing modulation

  title={Global identification of hnRNP A1 binding sites for SSO-based splicing modulation},
  author={Gitte Hoffmann Bruun and Thomas Koed Doktor and Jonas Borch-Jensen and Akio Masuda and Adrian R. Krainer and Kinji Ohno and Brage S Andresen},
  booktitle={BMC Biology},
Many pathogenic genetic variants have been shown to disrupt mRNA splicing. Besides splice mutations in the well-conserved splice sites, mutations in splicing regulatory elements (SREs) may deregulate splicing and cause disease. A promising therapeutic approach is to compensate for this deregulation by blocking other SREs with splice-switching oligonucleotides (SSOs). However, the location and sequence of most SREs are not well known. Here, we used individual-nucleotide resolution crosslinking… CONTINUE READING
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