Global identifiability of nonlinear models of biological systems

@article{Audoly2001GlobalIO,
  title={Global identifiability of nonlinear models of biological systems},
  author={Stefania Audoly and Giuseppina Bellu and Leontina D'Angi{\`o} and Maria Pia Saccomani and Claudio Cobelli},
  journal={IEEE Transactions on Biomedical Engineering},
  year={2001},
  volume={48},
  pages={55-65}
}
A prerequisite for well-posedness of parameter estimation of biological and physiological systems is a priori global identifiability, a property which concerns uniqueness of the solution for the unknown model parameters. Assessing a priori global identifiability is particularly difficult for nonlinear dynamic models. Various approaches have been proposed in the literature but no solution exists in the general case. Here, the authors present a new algorithm for testing global identifiability of… CONTINUE READING

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