Global hypoxia per se is an unusual cause of axonal injury

  title={Global hypoxia per se is an unusual cause of axonal injury},
  author={David Dolinak and Charles A. P. Smith and David I. Graham},
  journal={Acta Neuropathologica},
Irreversible hypoxic brain damage and axonal injury are present in over 90% of fatal blunt head injuries. Given the frequency of each, difficulties arise as to whether or not they are due to different mechanisms and, as such, can be separately recognised and quantified. Recent literature has raised the possible role of hypoxia in the formation of axonal bulbs. The present study of 17 cases of cardio-respiratory arrest, 12 of status epilepticus, 3 of carbon monoxide poisoning and 12 controls was… CONTINUE READING


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