Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia.

@article{Shimabukuro2007GlobalHO,
  title={Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia.},
  author={Morihiro Shimabukuro and Tsukasa Sasaki and Akira Imamura and Takahiro Tsujita and Chiaki Fuke and Tadashi Umekage and Mamoru Tochigi and Kennichi Hiramatsu and Tetsuji Miyazaki and Takaya Oda and Jun Sugimoto and Yoshihiro Jinno and Yuji Okazaki},
  journal={Journal of psychiatric research},
  year={2007},
  volume={41 12},
  pages={
          1042-6
        }
}
Genetic and epigenetic factors can potentially alter susceptibility to psychiatric disorders such as schizophrenia. In order to explore the effect of epigenetics on the pathogenesis of schizophrenia, we examined the global methylation level of leukocyte DNA from 210 patients with schizophrenia (124 males and 86 females) and 237 healthy subjects (108 males and 129 females). Methylated deoxycytidine (mC) content in peripheral leukocyte DNA was measured by high performance liquid chromatography… Expand
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