Global histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer.

@article{Tamagawa2013GlobalHM,
  title={Global histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer.},
  author={Hiroshi Tamagawa and Tomoko Oshima and Masakatsu Numata and Naoto Yamamoto and Manabu Shiozawa and Soichiro Morinaga and Yoshiyasu Nakamura and Mitsuyo Yoshihara and Yuji Sakuma and Yoichi Kameda and Makoto Akaike and Norio Yukawa and Yasushi Rino and Munetaka Masuda and Yumi Miyagi},
  journal={European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology},
  year={2013},
  volume={39 6},
  pages={655-61}
}
BACKGROUND We evaluated the methylation patterns of histone H3 lysine 27 (H3K27), H3 lysine 36 (H3K36) and the expression of H3K27 methylase EZH2 in patients with colorectal carcinomas with metachronous liver metastasis to search for biomarkers identifying these patients. METHODS Double 2-mm core tissue microarrays were made from 54 paraffin-embedded samples of primary colorectal adenocarcinomas and corresponding liver metastases and examined using an immunohistochemical analysis of… CONTINUE READING

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