Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes.

@article{Brown2008GlobalHA,
  title={Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes.},
  author={Christopher R. Brown and Caleb J. Kennedy and Valerie A. Delmar and Douglass J. Forbes and Pamela A. Silver},
  journal={Genes & development},
  year={2008},
  volume={22 5},
  pages={627-39}
}
The nuclear localization of genes is intimately tied to their transcriptional status in Saccharomyces cerevisiae, with populations of both active and silent genes interacting with components of the nuclear envelope. We investigated the relationship between the mammalian nuclear pore and the human genome by generating high-resolution, chromosome-wide binding maps of human nucleoporin 93 (Nup93) in the presence and absence of a potent histone deacetylase inhibitor (HDACI). Here, we report… CONTINUE READING

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