Global genetic differentiation of complex traits shaped by natural selection in humans

@inproceedings{Guo2018GlobalGD,
  title={Global genetic differentiation of complex traits shaped by natural selection in humans},
  author={Jing Guo and Yang Wu and Zhihong Zhu and Zhili Zheng and Maciej Trzaskowski and Jian Zeng and Matthew R Robinson and Peter M. Visscher and Jian Yang},
  booktitle={Nature Communications},
  year={2018}
}
There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess the differentiation in allele frequencies of trait-associated SNPs among African, Eastern Asian, and European populations for ten complex traits using data of large sample size (up to ~405,000). We show that SNPs associated with height ($$P = 2.46 \times 10^{ - 5}$$P=2.46×10-5), waist-to-hip… CONTINUE READING
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