Global gene expression profiling of human lung epithelial cells after exposure to nanosilver.

@article{Foldbjerg2012GlobalGE,
  title={Global gene expression profiling of human lung epithelial cells after exposure to nanosilver.},
  author={Rasmus Foldbjerg and Eveline S Irving and Yuya Hayashi and Duncan S Sutherland and Kasper Thorsen and Herman Autrup and Christiane Beer},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={130 1},
  pages={145-57}
}
The toxic effects of silver nanoparticles (AgNPs) on cells are well established, but only limited studies on the effect of AgNPs and silver ions on the cellular transcriptome have been performed. In this study, the effect of AgNPs on the gene expression in the human lung epithelial cell line A549 exposed to 12.1 µg/ml AgNPs (EC20) for 24 and 48h was compared with the response to control and silver ion (Ag(+)) treated cells (1.3 µg/ml) using microarray analysis. Twenty-four hours to AgNP altered… CONTINUE READING