Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray.

@article{Barrans2002GlobalGE,
  title={Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray.},
  author={J David Barrans and Paul D. Allen and Dimitrios Stamatiou and Victor J. Dzau and C M Liew},
  journal={The American journal of pathology},
  year={2002},
  volume={160 6},
  pages={2035-43}
}
To obtain a genomic portrait of heart failure derived from end-stage dilated cardiomyopathy (DCM), we explored expression analysis using the CardioChip, a nonredundant 10,848-element human cardiovascular-based expressed sequence tag glass slide cDNA microarray constructed in-house. RNA was extracted from the left ventricular free wall of seven patients undergoing transplantation, and five nonfailing heart samples. Cy3- and Cy5-labeled (and reverse dye-labeled) cDNA probes were synthesized from… CONTINUE READING

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