Global gene expression profiling of Yersinia pestis replicating inside macrophages reveals the roles of a putative stress-induced operon in regulating type III secretion and intracellular cell division.

@article{Fukuto2010GlobalGE,
  title={Global gene expression profiling of Yersinia pestis replicating inside macrophages reveals the roles of a putative stress-induced operon in regulating type III secretion and intracellular cell division.},
  author={Hana S. Fukuto and Anton Svetlanov and Lance E. Palmer and Abdul W. Karzai and James B Bliska},
  journal={Infection and immunity},
  year={2010},
  volume={78 9},
  pages={
          3700-15
        }
}
Yersinia pestis, the causative agent of plague, is a facultative intracellular pathogen. Previous studies have indicated that the ability of Y. pestis to survive inside macrophages may be critical during the early stages of plague pathogenesis. To gain insights into the biology of intracellular Y. pestis and its environment following phagocytosis, we determined the genome-wide transcriptional profile of Y. pestis KIM5 replicating inside J774.1 macrophage-like cells using DNA microarrays. At 1.5… CONTINUE READING
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