Global gene expression profiling and tissue microarray reveal novel candidate genes and down-regulation of the tumor suppressor gene CAV1 in sporadic vestibular schwannomas.

@article{Aarhus2010GlobalGE,
  title={Global gene expression profiling and tissue microarray reveal novel candidate genes and down-regulation of the tumor suppressor gene CAV1 in sporadic vestibular schwannomas.},
  author={Mads Aarhus and Ove Bruland and Hege Aase S{\ae}tran and Sverre J. Mork and Morten Lund-Johansen and Per Morten Knappskog},
  journal={Neurosurgery},
  year={2010},
  volume={67 4},
  pages={998-1019; discussion 1019}
}
BACKGROUND The vestibular nerve is the predilection site for schwannomas. Few transcriptomic studies have been performed on solely sporadic vestibular schwannomas (VSs). OBJECTIVE To detect genes with altered expression levels in sporadic VSs. METHODS We studied 25 VSs and 3 tibial nerves (controls) with the ABI 1700 microarray platform. Significance analysis of microarrays was performed to explore differential gene expression. Selected genes were validated with quantitative reverse… CONTINUE READING

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