Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p)ppGpp synthase

@article{BrockmannGretza2006GlobalGE,
  title={Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p)ppGpp synthase},
  author={Olaf Brockmann-Gretza and J{\"o}rn Kalinowski},
  journal={BMC Genomics},
  year={2006},
  volume={7},
  pages={1-15}
}
BackgroundThe stringent response is the initial reaction of microorganisms to nutritional stress. During stringent response the small nucleotides (p)ppGpp act as global regulators and reprogram bacterial transcription. In this work, the genetic network controlled by the stringent response was characterized in the amino acid-producing Corynebacterium glutamicum.ResultsThe transcriptome of a C. glutamicum rel gene deletion mutant, unable to synthesize (p)ppGpp and to induce the stringent response… CONTINUE READING

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