Global gene expression analysis reveals specific and redundant roles for H1 variants, H1c and H1(0), in gene expression regulation.

@article{Bhan2008GlobalGE,
  title={Global gene expression analysis reveals specific and redundant roles for H1 variants, H1c and H1(0), in gene expression regulation.},
  author={Sheetal Bhan and Warren May and Stephanie L Warren and Donald B. Sittman},
  journal={Gene},
  year={2008},
  volume={414 1-2},
  pages={10-8}
}
In mammals, the functional significance of the presence of evolutionarily conserved, multiple non-allelic H1 variants remains unclear. We used a unique overproduction approach coupled with cell cycle synchronization and early time point assays to assess differential effects of H1 variants, H1c and H1(0), on global gene expression in the absence of compensatory events that may mask variant-specific effects. We found that H1c and H1(0) act primarily as specific rather than global regulators of… CONTINUE READING

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