Global gene expression analysis in time series following N-acetyl L-cysteine induced epithelial differentiation of human normal and cancer cells in vitro

@article{Gustafsson2004GlobalGE,
  title={Global gene expression analysis in time series following N-acetyl L-cysteine induced epithelial differentiation of human normal and cancer cells in vitro},
  author={Anna C Gustafsson and Ilya Kupershmidt and Esther Edlundh-Rose and Giulia Greco and Annalucia Serafino and Eva K Krasnowska and Thomas Lundeberg and Luisa Bracci-Laudiero and Maria-Concetta Romano and Tiziana Parasassi and Joakim Lundeberg},
  journal={BMC Cancer},
  year={2004},
  volume={5},
  pages={75 - 75}
}
Cancer prevention trials using different types of antioxidant supplements have been carried out at several occasions and one of the investigated compounds has been the antioxidant N-acetyl-L-cysteine (NAC). Studies at the cellular level have previously demonstrated that a single supplementation of NAC induces a ten-fold more rapid differentiation in normal primary human keratinocytes as well as a reversion of a colon carcinoma cell line from neoplastic proliferation to apical-basolateral… CONTINUE READING

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