Global gene expression analysis in liver of obese diabetic db/db mice treated with metformin

@article{Heishi2006GlobalGE,
  title={Global gene expression analysis in liver of obese diabetic db/db mice treated with metformin},
  author={Masayuki Heishi and Junji Ichihara and Reiji Teramoto and Yasushi Itakura and Koji Hayashi and Hironori Ishikawa and Hiroshi Gomi and Juro Sakai and Masaharu Kanaoka and Mutsuo Taiji and Tōru Kimura},
  journal={Diabetologia},
  year={2006},
  volume={49},
  pages={1647-1655}
}
Metformin is widely used as a hypoglycaemic reagent for type 2 diabetes. While the reduction of hepatic gluconeogenesis is thought to be a key effect, the detailed molecular mechanism of action of metformin remains to be elucidated. To gain insight into this, we performed a global gene expression profiling study. We performed DNA microarray analysis to study global gene expression in the livers of obese diabetic db/db mice 2 h after a single administration of metformin (400 mg/kg). This… CONTINUE READING