Global fit analysis of glucose binding curves reveals a minimal model for kinetic cooperativity in human glucokinase.

Abstract

Human pancreatic glucokinase is a monomeric enzyme that displays kinetic cooperativity, a feature that facilitates enzyme-mediated regulation of blood glucose levels in the body. Two theoretical models have been proposed to describe the non-Michaelis-Menten behavior of human glucokinase. The mnemonic mechanism postulates the existence of one… (More)
DOI: 10.1021/bi1008672

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@article{Larion2010GlobalFA, title={Global fit analysis of glucose binding curves reveals a minimal model for kinetic cooperativity in human glucokinase.}, author={Mioara Larion and Brian G Miller}, journal={Biochemistry}, year={2010}, volume={49 41}, pages={8902-11} }