Global expression profiling of sex cord stromal tumors from Men1 heterozygous mice identifies altered TGF-beta signaling, decreased Gata6 and increased Csf1r expression.

@article{Mould2009GlobalEP,
  title={Global expression profiling of sex cord stromal tumors from Men1 heterozygous mice identifies altered TGF-beta signaling, decreased Gata6 and increased Csf1r expression.},
  author={Arne W Mould and Russell A Duncan and Magdalena M M Serewko-Auret and Kelly A. Loffler and Christine A Biondi and Michael G. Gartside and Graham F. Kay and N. K. Hayward},
  journal={International journal of cancer},
  year={2009},
  volume={124 5},
  pages={1122-32}
}
Heterozygous disruption of the Men1 gene predisposes mice to the development of multiple endocrine tumors, accurately mimicking the human MEN1 cancer predisposition syndrome. Additionally, Men1(+/-) mice frequently develop sex cord adenomas. The mechanism underlying the susceptibility of these mice to sex cord tumor development has not been fully determined, but data suggest it may involve transcriptional regulation of key growth promoting/repressing genes. To identify potential menin-regulated… CONTINUE READING