Global effects of vitamin A deficiency on gene expression in rat liver: evidence for hypoandrogenism.

@article{McClintick2006GlobalEO,
  title={Global effects of vitamin A deficiency on gene expression in rat liver: evidence for hypoandrogenism.},
  author={Jeanette N. McClintick and David W Crabb and Huijun Tian and Jane A. Pinaire and Jennifer R. Smith and Ronald E Jerome and Howard J. Edenberg},
  journal={The Journal of nutritional biochemistry},
  year={2006},
  volume={17 5},
  pages={345-55}
}
Vitamin A (retinol) metabolites are ligands for transcription factors that regulate many genes. The liver is the main storage depot for retinol and plays a role in vitamin A homeostasis. To better understand the effects of vitamin A deficiency on liver gene expression, we produced retinol deficiency in male rats by feeding a diet low in retinol for 53 days after weaning and examined the effects on gene expression in liver using Affymetrix oligonucleotide microarrays. We detected expression of… CONTINUE READING