Global effects of histone modifications.

  title={Global effects of histone modifications.},
  author={Hongpeng He and Norbert Lehming},
  journal={Briefings in functional genomics & proteomics},
  volume={2 3},
The relationship between chromatin structure and transcriptional regulation has been the focus of many research publications over the past few years. A lot of progress has been made in understanding the role of histone modifications. The interdependence of histone methylation and DNA methylation has been revealed. Methylation, acetylation, phosphorylation and ubiquitination of specific histone residues are all able to affect the DNA binding of transcription factors and to change the structure… CONTINUE READING

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