Global dynamics of hematopoietic stem cells and differentiated cells in a chronic myeloid leukemia model.

@article{Anseba2011GlobalDO,
  title={Global dynamics of hematopoietic stem cells and differentiated cells in a chronic myeloid leukemia model.},
  author={Bedr'eddine A{\"i}nseba and Chahrazed Benosman},
  journal={Journal of mathematical biology},
  year={2011},
  volume={62 6},
  pages={975-97}
}
We consider a mathematical model describing evolution of normal and leukemic hematopoietic stem cells (HSC) and differentiated cells in bone marrow. We focus on chronic myeloid leukemia (CML), a cancer of blood cells resulting from a malignant transformation of hematopoietic stem cells. The dynamics are given by a system of ordinary differential equations… CONTINUE READING