Global disturbances in autonomic function yield cardiovascular instability and hypertension in the chromogranin a null mouse.

@article{Gayen2009GlobalDI,
  title={Global disturbances in autonomic function yield cardiovascular instability and hypertension in the chromogranin a null mouse.},
  author={Jiaur Rahaman Gayen and Yusu Gu and Daniel T. O'Connor and Sushil K Mahata},
  journal={Endocrinology},
  year={2009},
  volume={150 11},
  pages={5027-35}
}
We reported previously that chromogranin A (Chga) knockout (KO) mice are hypertensive and hyperadrenergic. Here we sought to determine the basis of such alterations by probing physiological, biochemical, and pharmacological responses to perturbations of the autonomic nervous system. In the conscious state, KO mice had substantially elevated basal high blood pressure (BP) and heart rate (HR); immobilization stress caused increments in systolic BP and HR in both wild-type (WT) and KO mice, with… CONTINUE READING

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