Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis

  title={Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis},
  author={Fr{\'e}d{\'e}ric B Piel and Anand P. Patil and Rosalind E. Howes and Oscar A. Nyangiri and Peter W. Gething and Thomas N Williams and David J. Weatherall and Simon I. Hay},
  booktitle={Nature communications},
It has been 100 years since the first report of sickle haemoglobin (HbS). More than 50 years ago, it was suggested that the gene responsible for this disorder could reach high frequencies because of resistance conferred against malaria by the heterozygous carrier state. This traditional example of balancing selection is known as the 'malaria hypothesis'. However, the geographical relationship between the transmission intensity of malaria and associated HbS burden has never been formally… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 11 times over the past 90 days. VIEW TWEETS
114 Citations
94 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 114 extracted citations


Publications referenced by this paper.
Showing 1-10 of 94 references

Genetic variation in human HBB is associated with Plasmodium falciparum transmission

  • Gouagna, C L.
  • Nat. Genet
  • 2010

Abnormal haemoglobins in 4000 blood donors at Korle Bu

  • G. Yawson, E. C. Marbell
  • Pers . Com .
  • 2009

Genetic control of resistance to human malaria

  • A. C. Allison
  • Curr. Opin. Immunol
  • 2009

Plasmodium falciparum endemicity in 2007

  • Hay, S. I. et al. A world malaria map
  • PLoS Med. 6, e1000048
  • 2009

Similar Papers

Loading similar papers…