Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis

@inproceedings{Piel2010GlobalDO,
  title={Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis},
  author={Fr{\'e}d{\'e}ric B Piel and Anand P. Patil and Rosalind E. Howes and Oscar A. Nyangiri and Peter W. Gething and Thomas N Williams and David J. Weatherall and Simon I. Hay},
  booktitle={Nature communications},
  year={2010}
}
It has been 100 years since the first report of sickle haemoglobin (HbS). More than 50 years ago, it was suggested that the gene responsible for this disorder could reach high frequencies because of resistance conferred against malaria by the heterozygous carrier state. This traditional example of balancing selection is known as the 'malaria hypothesis'. However, the geographical relationship between the transmission intensity of malaria and associated HbS burden has never been formally… CONTINUE READING
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