Global distribution of a variant of the circumsporozoite gene of Plasmodium vivax.

@article{Kain1991GlobalDO,
  title={Global distribution of a variant of the circumsporozoite gene of Plasmodium vivax.},
  author={Kevin C Kain and Jay S. Keystone and Eileen D Franke and David E. Lanar},
  journal={The Journal of infectious diseases},
  year={1991},
  volume={164 1},
  pages={208-10}
}
The global distribution of a newly described variant of the Plasmodium vivax circumsporozoite (CS) gene was determined by genetic analysis of wild isolates. Whole blood specimens were collected on filter paper from patients infected with P. vivax in South America. West Africa, and the Indian subcontinent. P. vivax DNA was released from the filter paper samples, and the CS gene was amplified by polymerase chain reaction and analyzed for genetic variation. Amplified DNA was probed with… CONTINUE READING

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