Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3.

@article{Llorca2005GlobalCR,
  title={Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3.},
  author={Oscar Llorca and Ernesto Arias-Palomo and Jos{\'e} L Zugaza and Xos{\'e} R Bustelo},
  journal={The EMBO journal},
  year={2005},
  volume={24 7},
  pages={
          1330-40
        }
}
Activation of Rho/Rac GTPases during cell signaling requires the participation of GDP/GTP exchange factors of the Dbl family. Although the structure of the catalytic core of Dbl proteins has been established recently, the molecular changes that the full-length proteins experience during normal or oncogenic conditions of stimulation are still unknown. Here, we have used single-particle electron microscopy to solve the structures of the inactive (unphosphorylated), active (phosphorylated), and… CONTINUE READING
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