Global characterization of interferon regulatory factor (IRF) genes in vertebrates: Glimpse of the diversification in evolution

@inproceedings{Huang2009GlobalCO,
  title={Global characterization of interferon regulatory factor (IRF) genes in vertebrates: Glimpse of the diversification in evolution},
  author={Bei Huang and Zhi Qi and Zhen Zhu Xu and Pin Nie},
  booktitle={BMC Immunology},
  year={2009}
}
Interferon regulatory factors (IRFs), which can be identified based on a unique helix-turn-helix DNA-binding domain (DBD) are a large family of transcription factors involved in host immune response, haemotopoietic differentiation and immunomodulation. Despite the identification of ten IRF family members in mammals, and some recent effort to identify these members in fish, relatively little is known in the composition of these members in other classes of vertebrates, and the evolution and… CONTINUE READING