Global changes in genomic methylation levels during early development of the zebrafish embryo

@article{Mhanni2004GlobalCI,
  title={Global changes in genomic methylation levels during early development of the zebrafish embryo},
  author={Aizeddin A. Mhanni and Ross A. McGowan},
  journal={Development Genes and Evolution},
  year={2004},
  volume={214},
  pages={412-417}
}
We have examined the methylation status of the zebrafish genome during early embryogenesis and we find evidence that methylation fluxes do occur in that organism. The parental genetic contributions to the zygote are, initially, differently methylated with the genome of the sperm being hypermethylated relative to the genome of the oocyte. Post-fertilization there is an immediate decrease in methylation of the embryonic genome but the methylation begins to increase rapidly and is re-established… CONTINUE READING