Global cerebral ischemia due to cardiocirculatory arrest in mice causes neuronal degeneration and early induction of transcription factor genes in the hippocampus.

@article{Boettiger1999GlobalCI,
  title={Global cerebral ischemia due to cardiocirculatory arrest in mice causes neuronal degeneration and early induction of transcription factor genes in the hippocampus.},
  author={Bernd W. Boettiger and Peter Teschendorf and Jakub J. Krumnikl and Peter Vogel and Roland Galmbacher and Bernd Horst Schmitz and Johann Motsch and Eike Martin and Peter Gass},
  journal={Brain research. Molecular brain research},
  year={1999},
  volume={65 2},
  pages={
          135-42
        }
}
To analyze the role of specific genes and proteins in neuronal signaling cascades following global cerebral ischemia, it would be useful to have a reproducible model of global cerebral ischemia in mice that potentially allows the investigation of mice with specific genomic mutations. We first report on the development of a model of reversible cardiocirculatory arrest in mice and the consequences of such an insult to neuronal degeneration and expression of immediate early genes (IEG) in the… CONTINUE READING

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