Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

@inproceedings{Iwata2013GlobalBD,
  title={Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice},
  author={Nobuhisa Iwata and Misaki Sekiguchi and Yoshino Hattori and Akane Takahashi and Masashi Asai and Bin Ji and Makoto Higuchi and Matthias Staufenbiel and Shinichi Muramatsu and Takaomi C Saido},
  booktitle={Scientific reports},
  year={2013}
}
Accumulation of amyloid-β peptide (Aβ) in the brain is closely associated with cognitive decline in Alzheimer's disease (AD). Stereotaxic infusion of neprilysin-encoding viral vectors into the hippocampus has been shown to decrease Aβ in AD-model mice, but more efficient and global delivery is necessary to treat the broadly distributed burden in AD. Here we developed an adeno-associated virus (AAV) vector capable of providing neuronal gene expression throughout the brains after peripheral… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 31 CITATIONS

Gene therapy for a mouse model of glucose transporter-1 deficiency syndrome

  • Molecular genetics and metabolism reports
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND & METHODS

Meet Our Regional Editor

  • Current neuropharmacology
  • 2017

References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina.

  • Molecular therapy : the journal of the American Society of Gene Therapy
  • 2011

Ab aggregation and possible implications in Alzheimer’s disease pathogenesis

Bharadwaj, R P.
  • J. Cell. Mol. Med
  • 2009

Amyloid-b as a positive endogenous regulator of release probability at hippocampal synapses

E Abramov
  • Nat. Neurosci
  • 2009

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

Christine, W C.
  • Neurology 73,
  • 2009

Similar Papers

Loading similar papers…