Global and specific translational regulation in the genomic response of Saccharomyces cerevisiae to a rapid transfer from a fermentable to a nonfermentable carbon source.

@article{Kuhn2001GlobalAS,
  title={Global and specific translational regulation in the genomic response of Saccharomyces cerevisiae to a rapid transfer from a fermentable to a nonfermentable carbon source.},
  author={Kenneth M Kuhn and Joseph L. DeRisi and Patrick O. Brown and Peter Sarnow},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 3},
  pages={916-27}
}
The global gene expression program that accompanies the adaptation of Saccharomyces cerevisiae to an abrupt transfer from a fermentable to a nonfermentable carbon source was characterized by using a cDNA microarray to monitor the relative abundances and polysomal distributions of mRNAs. Features of the program included a transient reduction in global translational activity and a severe decrease in polysome size of transcripts encoding ribosomal proteins. While the overall translation initiation… CONTINUE READING
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