Global and Hox-specific roles for the MLL1 methyltransferase.

  title={Global and Hox-specific roles for the MLL1 methyltransferase.},
  author={Matthew G. Guenther and Richard G Jenner and B. I. Gilman And C. S. Peirce Jean - Marie Chevalier and Tatsuya Nakamura and Carlo M. Croce and Eli Canaani and Richard A. Young},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 24},
The mixed-lineage leukemia (MLL1/ALL-1/HRX) histone methyltransferase is involved in the epigenetic maintenance of transcriptional memory and the pathogenesis of human leukemias. To understand its role in cell type specification, we determined the human genomic binding sites of MLL1. We found that MLL1 functions as a human equivalent of yeast Set1. Like Set1, MLL1 localizes with RNA polymerase II (Pol II) to the 5' end of actively transcribed genes, where histone H3 lysine 4 trimethylation… CONTINUE READING
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