Global analysis of trans-splicing in Drosophila.

  title={Global analysis of trans-splicing in Drosophila.},
  author={Christine J McManus and Michael O. Duff and Jodi E. Eipper-Mains and Brenton R Graveley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 29},
Precursor mRNA (pre-mRNA) splicing can join exons contained on either a single pre-mRNA (cis) or on separate pre-mRNAs (trans). It is exceedingly rare to have trans-splicing between protein-coding exons and has been demonstrated for only two Drosophila genes: mod(mdg4) and lola. It has also been suggested that trans-splicing is a mechanism for the generation of chimeric RNA products containing sequence from multiple distant genomic sites. Because most high-throughput approaches cannot… CONTINUE READING
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